Infectious Diseases
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Infectious Diseases
A curation of the best Articles and Research on Infectious Diseases. (Not a news site, focus on ideas, research, solutions, protocols and discussions related infectious/communicable/tropical diseases.
Curated by nrip
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How SARS-CoV-2 first adapted in humans

How SARS-CoV-2 first adapted in humans | Infectious Diseases | Scoop.it

Viruses need entry proteins to penetrate the cells where they will replicate. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) version is called the spike or S protein.

 

The S protein, also the target of the current vaccines, is quickly adapting to its new human hosts. It took its first major step in this direction early in 2020, when its amino acid 614 (of 1297) changed from an aspartic acid (D) to a glycine (G). Viruses bearing this D614G mutation transmit among humans more rapidly and now form the majority in circulation.

 

On page 525 of this issue, Zhang et al. (1) use careful structural analyses to reveal how D614G changed the S protein to accelerate the pandemic.

 

The work of Zhang et al. also reveals more about the natural history of the virus. The notable emergence of D614G suggests that the acquisition of a destabilizing furin site was a recent event. The virus could easily lose this site, as it does frequently in cell culture systems, implying that it in some way facilitates human transmission.

 

This is not a conclusion that most students of human coronaviruses would have anticipated, given that SARS-CoV-1, which transmits with reasonable efficiency, lacks this site, whereas the more distantly related MERS coronavirus bears this site and transmits poorly. How the SARS-CoV-2 furin site promotes new human infections remains a key open question in the field.

 

read the entire article at https://science.sciencemag.org/content/372/6541/466

 

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Surveillance for emerging respiratory viruses

Surveillance for emerging respiratory viruses | Infectious Diseases | Scoop.it

Several new viral respiratory tract infectious diseases with epidemic potential that threaten global health security have emerged in the past 15 years. In 2003, WHO issued a worldwide alert for an unknown emerging illness, later named severe acute respiratory syndrome (SARS). The disease caused by a novel coronavirus (SARS-CoV) rapidly spread worldwide, causing more than 8000 cases and 800 deaths in more than 30 countries with a substantial economic impact.

 

Since then, we have witnessed the emergence of several other viral respiratory pathogens including influenza viruses (avian influenza H5N1, H7N9, and H10N8; variant influenza A H3N2 virus), human adenovirus-14, and Middle East respiratory syndrome coronavirus (MERS-CoV).

 

In response, various surveillance systems have been developed to monitor the emergence of respiratory-tract infections. These include systems based on identification of syndromes, web-based systems, systems that gather health data from health facilities (such as emergency departments and family doctors), and systems that rely on self-reporting by patients.

 

More effective national, regional, and international surveillance systems are required to enable rapid identification of emerging respiratory epidemics, diseases with epidemic potential, their specific microbial cause, origin, mode of acquisition, and transmission dynamics.

nrip's insight:

This was part of the literature which influenced MediXcel Disease Surveillance and Early Warning system which was in its infancy in 2012 to start adding Syndrome based surveillance layers, then expand them with Social Media data overlays and then use NLP and ML modeling to reach where it has reached today. Good to find it in my bookmarks and share it here today

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