Vascular disease can appropriately be described as the balance between vascular injury and vascular repair (Figure 1). The endothelium is strategically found to be closely associated to the bloodstream as well as the vascular smooth muscle and it is also in charge of discharging a variety of substances in order to preserve vascular homeostasis and health (Figures 2 and 3). Numerous irritations which can provoke damage or harm to the endothelium, can lead to endothelial dysfunction, or ED, and can cause hypertension and other cardiovascular diseases.
Hypertension might be a hemodynamic indication of a damaged or injuried endothelium and vascular smooth muscle which could be connected to definite inflammation responses, oxidative stress and immune dysfunction of the arteries leading to ED, vascular and cardiac smooth muscle disorder, loss of arterial elasticity together with reduced arterial compliance and increased systemic vascular resistance. Hypertension is a significant outcome of the interaction between environmental factors and genetics. Macronutrients and micronutrients are crucial in the regulation of blood pressure, or BP, following target organ damage, or TOD. Nutrient-gene interactions, subsequent gene expression, epigenetics, oxidative stress, inflammation and autoimmune vascular dysfunction have positive or negative influences on vascular biology in humans. Endothelial activation with endothelial dysfunction and vascular smooth muscle breakdown, or VSMD, can ultimately trigger and continue to stimulate the development and growth of hypertension.
Among the numerous risk factors which can lead to cardiovascular disease and hypertension, dietary and nutritional imbalances are among some of the most prevalent causes behind heart health issues. While vitamin and mineral deficiencies have been commonly linked to the development of CVD and hypertension, amino acids can be just as important towards heart health. For more information, please feel free to ask Dr. Jimenez or contact us at (915) 850-0900.